H. pylori (Helicobacter pylori)

A bacteria found in the stomach and is known to cause ulcers and sometimes stomach cancer and other digestive issues.
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ESSENTIAL RESEARCH
Helicobacter pylori infection and the development of gastric cancer.
Gastric cancer develops in persons infected with H. pylori but not in uninfected persons. Those with histologic findings of severe gastric atrophy, corpus-predominant gastritis, or intestinal metaplasia are at increased risk. Persons with H. pylori infection and nonulcer dyspepsia, gastric ulcers, or gastric hyperplastic polyps are also at risk, but those with duodenal ulcers are not.
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CLINICAL TRIALCompleted
Tailored Juice-guided Eradication Therapy, Randomized Controlled Trial
Kaohsiung, Taiwan
All genders
In this study, the investigators aim to investigate the efficacy of tailored anti-microbial susceptibility guided-therapy via gastric juice PCR, compared with empirical standard triple therapy.
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0REPLY2 DAYS AGO
NEW TREATMENT ADDED BY A MEMBER
Mastic Gum supplements
20 ratings
Does not have scientific evidence that it can eradiate H Pylori but some people have reported positive results.
OTC
TRIED
TRYING
How effective is it?
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completely cured
significant improvement
minor improvement
no difference
worse than before
Helps with prevention
1 (5%)
2 (10%)
6 (30%)
10 (50%)
1 (5%)
ESSENTIAL RESEARCH
Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report.
The global burden of gastric cancer is considerable but varies geographically. Eradication of H pylori infection has the potential to reduce the risk of gastric cancer development.
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NEW SYMPTOM ADDED BY A MEMBER
Yes
32
No
4
Stomach ache (Abdominal Pain)
89% reported this symptom
Pain in the stomach.
Can H.Pylori cause a low grade fever (37.5)?
Hello, I was recently diagnosed with H.Pylori but have not yet started the cure. However, the last days I’ve experienced a fever of 37.5 degrees celcius mostly going up in the afternoons/evenings and then going down in the mornings. Can this be a reaction of H.Pylori or it does not cause a fever?
0REPLY1 MONTH AGO
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ESSENTIAL RESEARCH
A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain.
The Sydney strain of H. pylori is available to all and will provide a standardized mouse model for vaccine development, compound screening, and studies in pathogenesis.
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NEW TREATMENT ADDED BY A MEMBER
Amoxicillin + Rifabutin + Ciprofloxacin + PPI
17 ratings
A quadruple therapy for those who failed a triple therapy.
Prescription
TRIED
TRYING
How effective is it?
REMOVE ANSWER
completely cured
significant improvement
minor improvement
no difference
worse than before
Helps with prevention
12 (71%)
1 (6%)
1 (6%)
3 (18%)
0 (0%)
PROGRESS UPDATE
SYMPTOM
Ear pain (Earache) marked as minimal
Stool color and texture changes marked as moderate
Brain fog marked as mild
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0REPLY1 WEEK AGO
NEW SYMPTOM ADDED BY A MEMBER
Yes
30
No
5
Burping (Belching)
86% reported this symptom
The release of gas from the digestive tract (mainly esophagus and stomach) through the mouth.
ESSENTIAL RESEARCH
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
We found that the incidence of gastric cancer development at the population level was similar between participants receiving H pylori eradication treatment and those receiving placebo during a period of 7.5 years in a high-risk region of China. In the subgroup of H pylori carriers without precancerous lesions, eradication of H pylori significantly decreased the development of gastric cancer. Further studies to investigate the role of H pylori eradication in participants with precancerous lesions are warranted.
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CLINICAL TRIALCompleted
PPI vs H2RA in Patients With Helicobacter Pylori-Negative Idiopathic Bleeding Ulcers
Hong Kong, China
All genders
Phase 4
The aim of this study is to compare the efficacy of a proton pump inhibitor (lansoprazole) and a histamine-2 receptor antagonist (famotidine) in preventing recurrent ulcer bleeding in patients with a history of H. pylori-negative idiopathic peptic ulcers.
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0REPLY2 WEEKS AGO
NEW TREATMENT ADDED BY A MEMBER
Amoxicillin + Clarithromycin + PPI
15 ratings, 1 reviews
A prescription combination of Amoxicillin, Clarithromycin, and a proton pump inhibitor taken at the same time.
Prescription
TRIED
TRYING
How effective is it?
REMOVE ANSWER
completely cured
significant improvement
minor improvement
no difference
worse than before
Helps with prevention
9 (60%)
2 (13%)
1 (7%)
2 (13%)
1 (7%)
PROGRESS UPDATE
TREATMENT
Trying treatment Amoxicillin + Clarithromycin + PPI
0REPLY2 WEEKS AGO
After H Pylori treatment
I have been affected with H Pylori for 3 months and i have been give antibiotics for 14 days and after 1 month , i was tested H Pylori negative.But its been 2 months from the test , i am experiencing dry eyes, dry mouth and headache like migraine.I even took the stool test again and the result still shows negative.I am thinking whether i got sjogren's syndrome.I am not sure what is happening.
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1REPLY7 MONTHS AGO
ESSENTIAL RESEARCH
Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial.
Prophylactic eradication of H pylori after endoscopic resection of early gastric cancer should be used to prevent the development of metachronous gastric carcinoma.
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ESSENTIAL RESEARCH
Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts.
These results suggest that 5.9 is the best estimate of the relative risk of non-cardia cancer associated with H pylori infection and that H pylori does not increase the risk of cardia cancer. They also support the idea that when H pylori status is assessed close to cancer diagnosis, the magnitude of the non-cardia association may be underestimated.
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ESSENTIAL RESEARCH
Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection.
When compared with uninfected subjects, persons infected with CagA positive H pylori are at considerably increased risk of gastric cancer. CagA negative H pylori are less strongly linked to malignancy and may only be associated with diffuse type disease.
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CLINICAL TRIALCompleted
Comparison Between Quadruple Regimens for Helicobacter Pylori Infection in Egypt
Zagazig, Egypt
All genders
Phase 4
The overall prevalence of H. Pylori in the developing countries is 50.8%, with the highest one presented in Africa (79.1%). Hybrid therapy is supposed to be more effective as a first-line regimen for Helicobacter pylori infection in Egypt than the Reverse hybrid and non-bismuth Levofloxacin quadruple therapies. We are aiming here to compare the Hybrid, Reverse hybrid, and Levofloxacin quadruple therapies as first-line therapy, trying to reach the safest, cost-effective, and compliance-inducing regimen in Egypt. We will conduct a randomized controlled (interventional) study at Zagazig University Hospital, internal medicine department clinic, on 330 patients. 110 patients will be allocated to each regimen.
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0REPLY3 WEEKS AGO
ESSENTIAL RESEARCH
Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms.
A proinflammatory cytokine genetic profile increases the risk of noncardia gastric adenocarcinoma but not other upper gastrointestinal cancers, possibly by inducing a hypochlorhydric and atrophic response to gastric H. pylori infection.
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ABOUT
A bacteria found in the stomach and is known to cause ulcers and sometimes stomach cancer and other digestive issues.
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