H. pylori (Helicobacter pylori)

A bacteria found in the stomach and is known to cause ulcers and sometimes stomach cancer and other digestive issues.
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ESSENTIAL RESEARCH
Serum pepsinogen 1 and anti-Helicobacter pylori IgG antibodies as predictors of gastric cancer risk in Finnish males.
Low SPG1 was associated with increased gastric cancer risk in our large Finnish cohort. A single measurement of SPG1 along with H. pylori whole cell and CagA serology provides potentially useful prediction of gastric cancer risk.
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0REPLY4 HOURS AGO
ESSENTIAL RESEARCH
Efficacy and safety of Helicobacter pylori eradication therapy immediately after endoscopic submucosal dissection.
This study failed to demonstrate the non-inferiority of immediate H. pylori eradication therapy after ESD to the non-eradication therapy in the healing rate of ESD-caused ulcers. However, because the failure is likely to attribute to small number of patients enrolled, immediate eradication therapy may be a treatment option for patients after ESD without adverse effects on eradication therapy in comparison with the standard therapy.
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0REPLY1 DAY AGO
NEW TREATMENT ADDED BY A MEMBER
Mastic Gum supplements
20 ratings
Does not have scientific evidence that it can eradiate H Pylori but some people have reported positive results.
OTC
TRIED
TRYING
How effective is it?
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completely cured
significant improvement
minor improvement
no difference
worse than before
Helps with prevention
1 (5%)
2 (10%)
6 (30%)
10 (50%)
1 (5%)
ESSENTIAL RESEARCH
Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta-analysis.
This meta-analysis suggests that infection of the gallbladder with Helicobacter pylori is closely related to an increased risk of chronic cholecystitis and cholelithiasis.
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0REPLY2 DAYS AGO
NEW SYMPTOM ADDED BY A MEMBER
Yes
31
No
4
Stomach ache (Abdominal Pain)
89% reported this symptom
Pain in the stomach.
ESSENTIAL RESEARCH
Helicobacter pylori Depletes Cholesterol in Gastric Glands to Prevent Interferon Gamma Signaling and Escape the Inflammatory Response.
H pylori expression of cgt reduces cholesterol levels in infected gastric epithelial cells and thereby blocks IFNG signaling, allowing the bacteria to escape the host inflammatory response. These findings provide insight into the mechanisms by which H pylori might promote gastric carcinogenesis (persisting despite constant inflammation) and ineffectiveness of T-cell-based vaccines against H pylori.
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0REPLY3 DAYS AGO
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ESSENTIAL RESEARCH
Levels of malondialdehyde in the gastric juice: Its association with Helicobacter pylori infection and stomach diseases.
Malondialdehyde in gastric juice could be used as a potential diagnostic biomarker for H. pylori infection and associated gastric diseases. The gastric juice MDA levels increased proportionally with the severity of gastric diseases.
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0REPLY4 DAYS AGO
ESSENTIAL RESEARCH
Helicobacter pylori moderates the association between 5-MTHF concentration and cognitive function in older adults.
The interaction between Helicobacter pylori seropositivity and reduced folate-cycle factor 5-methyltetrahydrofolate might impair aspects of cognitive function.
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0REPLY5 DAYS AGO
NEW TREATMENT ADDED BY A MEMBER
Amoxicillin + Rifabutin + Ciprofloxacin + PPI
17 ratings
A quadruple therapy for those who failed a triple therapy.
Prescription
TRIED
TRYING
How effective is it?
REMOVE ANSWER
completely cured
significant improvement
minor improvement
no difference
worse than before
Helps with prevention
12 (71%)
1 (6%)
1 (6%)
3 (18%)
0 (0%)
ESSENTIAL RESEARCH
Meta-analysis: High-dose vs. low-dose metronidazole-containing therapies for Helicobacter pylori eradication treatment.
Both high-dose and low-dose therapies can achieve similar eradication rates and adherence and generally low-dose therapies cause fewer side effects. In populations with high metronidazole resistance, high dose of metronidazole can increase the eradication rates of H. pylori infection.
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0REPLY6 DAYS AGO
ESSENTIAL RESEARCH
Detection and genotyping of Helicobacter pylori in saliva versus stool samples from asymptomatic individuals in Northeastern Thailand reveals intra-host tissue-specific H. pylori subtypes.
This study reports a high prevalence of H. pylori infection in asymptomatic persons in this region of Thailand and demonstrates that genotypes (vacA gene sequences) of H. pylori may differ between the oral cavity and intestinal tract.
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0REPLY1 WEEK AGO
CLINICAL TRIALEnrolling by invitation
CANHelp Working Group Treatment Trials
Edmonton, Canada
All genders
Phase 4
The CANHelp Working Group Treatment Trials are part of a comprehensive research program carried out by the Canadian North Helicobacter pylori (CANHelp) Working Group. The treatment component involves a series of community-specific trials designed with community input and varying on the specific treatment regimens and number of treatment arms among other study details.
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0REPLY1 WEEK AGO
ESSENTIAL RESEARCH
Novel epigenetic markers for gastric cancer risk stratification in individuals after Helicobacter pylori eradication.
Novel epigenetic markers for gastric cancer risk optimized for H. pylori-eradicated individuals were established.
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0REPLY1 WEEK AGO
ESSENTIAL RESEARCH
Anti-Helicobacter pylori therapy in localized gastric mucosa-associated lymphoid tissue lymphoma: A prospective, nationwide, multicenter study in Japan.
Rabeprazole-based H. pylori eradication therapy demonstrated a high CR rate, long CR maintenance, and a good OS for patients with localized gastric MALT lymphoma in this prospective, practice-based, multicenter study.
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0REPLY1 WEEK AGO
ESSENTIAL RESEARCH
Diagnostic accuracy of demarcation using magnifying endoscopy with narrow-band imaging for Helicobacter pylori-uninfected undifferentiated-type early gastric cancer.
Because neutrophil infiltration was classified as mild or none, the accuracy of diagnostic demarcation was high in the H. pylori-uninfected and H. pylori eradication groups.
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0REPLY1 WEEK AGO
CLINICAL TRIALCompleted
Dexlansoprazole MR-Based Concomitant Quadruple Therapy
Kaohsiung, Taiwan
All genders
Background: Recommended proton pump inhibitor (PPI)-clarithromycin-amoxicillin or metronidazole treatment for 7 to14 days is the first choice treatment for H pylori infection. The eradication rate of the standard triple therapy has generally declined to unacceptable levels (i.e., 80% or less) recently because the increasing incidence of clarithromycin-resistant strains of H. pylori. Standard triple therapies should be abandoned in the areas with clarithromycin resistance ≥ 20%. The investigators have proven that 7-day Concomitant therapy can achieve a promising success rate of >90 % in the presence of clarithromycin resistance. However, high dose PPI is needed with a dosage of twice daily but when a dual delayed release formulation PPI in capsules for oral administration (Dexlansoprazole MR), a once daily dose may be needed only. The capsules contain dexlansoprazole in a mixture of two types of enteric-coated granules with different pH-dependent dissolution profiles. It suppresses gastric acid secretion via inhibition of the proton pump in the gastric parietal cell, which blocks the final step of acid production. Thus, it improves acid suppression and offer benefits over conventional single release PPI formulations. by prolonging optimal plasma concentration and create a favorable condition H. pylori eradication Aim: The efficacy of Dexlansoprazole MR-based concomitant quadruple therapy
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0REPLY1 WEEK AGO
ESSENTIAL RESEARCH
Association between gastrointestinal tract infections and glycated hemoglobin in school children of poor neighborhoods in Port Elizabeth, South Africa.
The role of H. pylori in diabetes needs confirmation in the context of longitudinal treatment interventions. The specific effect of other gastrointestinal tract infections on glycemia remains unclear. Future studies should integrate the measurement of biomarkers, including immunological parameters, to shed light on the potential mediating mechanisms between parasite infections and diabetes.
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0REPLY1 WEEK AGO
CLINICAL TRIALCompleted
Compare Sequential and Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea
Seongnam-si, Korea, Republic of
All genders
1. To compare 10-day sequential therapy and 14-day modified bismuth quadruple therapy and to establish more effective first-line regimen for the eradication of Helicobacter pylori in Korea. 2. To evaluate the effect of H. pylori eradication therapy on the symptom improvement of functional dyspepsia
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0REPLY1 WEEK AGO
ESSENTIAL RESEARCH
Non-invasive diagnostic tests for Helicobacter pylori infection.
In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.
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0REPLY1 WEEK AGO
ESSENTIAL RESEARCH
Effects of Helicobacter pylori Treatment on Incidence of Gastric Cancer in Older Individuals.
In an analysis of data from a public hospital database on Hong Kong, we associated treatment of H pylori infection with a lower risk of gastric cancer, particularly in older subjects, 10 or more years after treatment.
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0REPLY1 WEEK AGO
ESSENTIAL RESEARCH
Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer.
Patients with early gastric cancer who received H. pylori treatment had lower rates of metachronous gastric cancer and more improvement from baseline in the grade of gastric corpus atrophy than patients who received placebo. (Funded by the National Cancer Center, South Korea; ClinicalTrials.gov number, NCT02407119 .).
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0REPLY1 WEEK AGO
ESSENTIAL RESEARCH
Th-17 response and antimicrobial peptide expression are uniformly expressed in gastric mucosa of Helicobacter pylori-infected patients independently of their clinical outcomes.
This study showed that CXCL-8, IL-17A, and AMPs are not differently expressed according to the various H. pylori -related diseases. The clinical outcome determinism of H. pylori infection is most likely not driven by gastric inflammation but rather tends to mainly influenced by bacterial virulence factors.
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0REPLY1 WEEK AGO
ESSENTIAL RESEARCH
Classification of atrophic mucosal patterns on Blue LASER Imaging for endoscopic diagnosis of Helicobacter pylori-related gastritis: A retrospective, observational study.
The Spotty pattern may represent the presence of HP infection, the Cracked pattern, a post-inflammatory change as seen after HP eradication, and the Mottled pattern, intestinal metaplasia.
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0REPLY1 WEEK AGO
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A bacteria found in the stomach and is known to cause ulcers and sometimes stomach cancer and other digestive issues.
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