H. pylori (Helicobacter pylori)

A bacteria found in the stomach and is known to cause ulcers and sometimes stomach cancer and other digestive issues.
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CLINICAL TRIALCompleted
Tailored Juice-guided Eradication Therapy, Randomized Controlled Trial
Kaohsiung, Taiwan
All genders
In this study, the investigators aim to investigate the efficacy of tailored anti-microbial susceptibility guided-therapy via gastric juice PCR, compared with empirical standard triple therapy.
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0REPLY2 DAYS AGO
CLINICAL TRIALCompleted
PPI vs H2RA in Patients With Helicobacter Pylori-Negative Idiopathic Bleeding Ulcers
Hong Kong, China
All genders
Phase 4
The aim of this study is to compare the efficacy of a proton pump inhibitor (lansoprazole) and a histamine-2 receptor antagonist (famotidine) in preventing recurrent ulcer bleeding in patients with a history of H. pylori-negative idiopathic peptic ulcers.
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0REPLY2 WEEKS AGO
CLINICAL TRIALCompleted
Comparison Between Quadruple Regimens for Helicobacter Pylori Infection in Egypt
Zagazig, Egypt
All genders
Phase 4
The overall prevalence of H. Pylori in the developing countries is 50.8%, with the highest one presented in Africa (79.1%). Hybrid therapy is supposed to be more effective as a first-line regimen for Helicobacter pylori infection in Egypt than the Reverse hybrid and non-bismuth Levofloxacin quadruple therapies. We are aiming here to compare the Hybrid, Reverse hybrid, and Levofloxacin quadruple therapies as first-line therapy, trying to reach the safest, cost-effective, and compliance-inducing regimen in Egypt. We will conduct a randomized controlled (interventional) study at Zagazig University Hospital, internal medicine department clinic, on 330 patients. 110 patients will be allocated to each regimen.
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0REPLY3 WEEKS AGO
CLINICAL TRIALCompleted
ARJ C13 Urea Breath Test System
6 Locations
All genders
Phase 2
An open-label, comparative group study to evaluate the equivalency of the PyloPlus 13C Urea Breath Test to predicate devices on the market.
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0REPLY3 WEEKS AGO
CLINICAL TRIALRecruiting
Long-term Follow-up of Interleukin-1B and H+,K+-ATPase mRNA Expression After Helicobacter Pylori Eradication
Seongnam-si, Korea, Republic of
All genders
We will evaluate the long-term changes of gastric H+, K+-adenosine triphosphatase (H+, K+-ATPase) and Interleukin-1B mRNA expression according to Helicobacter pylori (H.pylori) infection and intestinal metaplasia and investigate the long-term effect of H. pylori eradication
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0REPLY3 WEEKS AGO
CLINICAL TRIALNot yet recruiting
Effect of Probiotics on Helicobacter Pylori Eradication
All genders
Phase 4
The purpose of this clinical trial is to evaluate the clinical efficacy of Bifidobacterium quadruple live bacteria tablets (Si Lian Kang) on reducing the incidence rate of adverse reactions of Helicobacter pylori quadruple eradication therapy and its influence on gastrointestinal flora.
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0REPLY3 WEEKS AGO
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CLINICAL TRIALRecruiting
The Associations Between the Gastric Mucosal Pathology and the Eradication Rate of H.Pylori :A Multicenter Study
Jinan, China
All genders
Use the two-categorical variable , eradicate success or failure ,as a dependent variable, and analyze the influential factors by logistic regression.And then the statistically significant influencing factors like gastric mucosal pathology are obtained.We build a predictive model of the outcome of Hp eradication therapy based on significant influencing factors. The difference with p 0.05 is statistically significant.
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0REPLY4 WEEKS AGO
CLINICAL TRIALRecruiting
The Study of the Antimicrobial Resistance of Helicobacter Pylori in Shandong Province
Jinan, China
All genders
The antimicrobial resistance of helicobacter pylori in Shandong province was analyzed by helicobacter pylori antibiotic sensitivity test.And the map of antimicrobial resistance of helicobacter pylori was constructed to provide clinical guidance for selecting effective eradication program and improve the eradication rate.
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0REPLY4 WEEKS AGO
CLINICAL TRIALRecruiting
The Situation of Re-infection of Helicobacter Pylori After Successful Eradication
Jinan, China
All genders
The patients who accept the quadruple eradication program of the helicobacter pylori and success to eradicate helicobacter pylori will be followed-up to observe the situation of re-infection of helicobacter pylori.
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0REPLY4 WEEKS AGO
CLINICAL TRIALNot yet recruiting
Effectiveness of GastimunHp Plus in Supporting the Treatment of Peptic Ulcer Disease With Helicobacter Pylori Infection
All genders
Challenges in the treatment of Helicobacter pylori (H. pylori) include increasing antimicrobial resistance and patient's low tolerance to some regimens. Lactobacillus johnsonii (L. johnsonii) and Immunoglobulin Y (IgY) have been shown to decrease the amount and activity of H. pylori in human stomach and can increase patient's tolerance. We conduct a single-center double-masked randomized controlled trial to evaluate the effectiveness of GastimunHp Plus (a product combining L. johnsonii and IgY) in improving the clearance of H. pylori after six to eight weeks of treatment and side effects of H. pylori treatment. H. pylori is tested by C13- or C14-urea breath test.
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0REPLY1 MONTH AGO
CLINICAL TRIALRecruiting
High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori RescueTreatment
Shanghai, China
All genders
Phase 4
Dual therapy containing high dose of proton pump inhibitor (PPI) and amoxicillin had showed excellent eradication results with Helicobacter pylori first-line treatment. However, no study has examined the the efficacy of high dose of dual therapy or dual therapy plus metronidazole for H. pylori rescue treatment.This study is designed to evaluate the efficacy and safety of the addition of metronidazole to high dose of dual therapy for H. pylori rescue treatment.
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0REPLY1 MONTH AGO
CLINICAL TRIALNot yet recruiting
Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach
5 Locations
All genders
The study is aimed to determine the potential of volatile marker testing for gastric cancer screening. The study will be addressing the role of confounding factors, including lifestyle factors, diet, smoking as well as addressing the potential role of microbiota in the composition of exhaled volatile markers.
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0REPLY1 MONTH AGO
CLINICAL TRIALRecruiting
Diagnosis of Helicobacter Pylori Based on Gastric Collecting Venules
Barcelona, Spain
All genders
Helicobacter pylori (Hp) is the major cause of gastritis and gastritis-associated diseases. Detection of a regular arrangement of collecting venules (RAC) pattern in the lesser gastric curvature correlates with negative Hp status with a sensitivity and negative predictive value (NPV) higher than 90% in Asian countries. In a recent study carried out in our hospital, it has been shown that the presence of RAC pattern in the lesser gastric curvature, evaluated with high definition endoscopy, can accurately identify patients without Hp. The aim of this study is to confirm the validity of the endoscopic diagnosis of Hp infection in the West by means of the RAC pattern in a multicenter prospective study and to evaluate interobserver variability before establishing its applicability in clinical practice.
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0REPLY1 MONTH AGO
CLINICAL TRIALNot yet recruiting
Assesment of the Efficiency and Safety Helicobacter Pylori Therapy With or Without Saccharomyces Boulardii
All genders
Phase 4
This study assesses the effect of quadruple therapy for H. pylori, with the addition of probiotics Saccharomyces boulardii. In addition, he assesses whether this combination reduces the frequency of adverse effects of eradication therapy, and whether it affects the compliance.
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0REPLY1 MONTH AGO
CLINICAL TRIALCompleted
Effects of Different Omeprazole Dosing on Gastric pH in Non-variceal Upper Gastrointestinal Bleeding
Białystok, Poland
All genders
Phase 4
The aim of the study is to identify the best method of omeprazole (OME) application with respect to intragastric pH, cytochrome P450 2C19 (CYP2C19) genotype and phenotype.
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0REPLY2 MONTHS AGO
CLINICAL TRIALRecruiting
Effect of Helicobacter Pylori Eradication After Subtotal Gastrectomy on Survival Rate of Gastric Cancer Patients: Retrospective Study
Seongnam-si, Korea, Republic of
All genders
In this study, we will observe the long-term survival rate, overall mortality rate, gastric cancer specific mortality rate, and the incidence rate of metachronous cancer in patients who received subtotal gastrectomy, with or without Helicobacter pylori eradication.
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0REPLY2 MONTHS AGO
CLINICAL TRIALRecruiting
Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.
Xi`an, China
All genders
To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
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0REPLY2 MONTHS AGO
CLINICAL TRIALRecruiting
Dual-focus Magnification With Narrow-band Imaging in Helicobacter Pylori Infection
Seoul, Korea, Republic of
All genders
Dual-focus with narrow-band imaging (DF-NBI) is a novel technique to improve the quality of images of the irregular mucosal structures and microvessels of gastric neoplasms. The investigators compare this technique with conventional white light (WL) endoscopy to predict Helicobacter pylori infection.
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0REPLY2 MONTHS AGO
CLINICAL TRIALCompleted
ADDITION OF BISMUTH TO THE STANDARD TRIPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION
Karachi, Pakistan
All genders
Phase 2
H pylori is an important cause of chronic gastritis and other complications. There is a decline in eradication rate for H pylori owing to multiple factors including drug resistance. We compare the effect of the addition of bismuth to the standard triple therapy in a randomized control trial. Subjects were randomized into two arms. Arm A received triple therapy including amoxicillin, clarithromycin, and omeprazole and Arm B received quadruple therapy adding colloidal bismuth subcitrate. Both arms received treatment for two weeks.
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0REPLY2 MONTHS AGO
CLINICAL TRIALActive, not recruiting
Gastric Cancer Prevention in the Family Members by Helicobacter Pylori Eradication
Goyang, Korea, Republic of
All genders
Phase 3
This study evaluate whether treatment of Helicobacter pylori infection reduces the incidence of gastric cancer in subjects with family history of gastric cancer.
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0REPLY2 MONTHS AGO
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A bacteria found in the stomach and is known to cause ulcers and sometimes stomach cancer and other digestive issues.
SHOW MORE
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