Irritable bowel syndrome (IBS)

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NEW TREATMENT ADDED BY A MEMBER
Cannabis (marijuana, marihuana)
Some studies suggest marijuana can be an effective treatment for IBS.
52% of users reported improvements
Prescription
OTC
TRIED
TRYING
How effective is it?
REMOVE ANSWER
completely cured
significant improvement
minor improvement
no difference
worse than before
Helps with prevention
1 (5%)
4 (19%)
6 (29%)
7 (33%)
3 (14%)
ESSENTIAL RESEARCH
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.
Colonic mast cell infiltration and mediator release in proximity to mucosal innervation may contribute to abdominal pain perception in IBS patients.
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NEW SYMPTOM ADDED BY A MEMBER
Yes
9
No
0
Excessive gas
100% reported this symptom
Frequent farting or burping.
PROGRESS UPDATE
TREATMENT
Trying treatment Probiotics
Trying treatment FODMAP diet
Diet, gluten-free made a minor improvement
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SYMPTOM
Stomach ache (Abdominal Pain) marked as severe
Excessive gas marked as severe
Bloating marked as moderate
Show 16 more
1REPLY2 YEARS AGO
CLINICAL TRIALNot yet recruiting
Helicobacter Pylori Eradication and Irritable Bowel Syndrome: A Prospective Study
All genders
Phase 4
H. Pylori is frequently observed in patients with irritable bowel syndrome(IBS). However, the effect of H. pylori eradication on IBS is not clear.
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0REPLY1 YEAR AGO
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ESSENTIAL RESEARCH
Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis.
The prevalence of IBS varies among countries, as well as criteria used to define its presence. Women are at slightly higher risk for IBS than men. The effects of socioeconomic status have not been well described.
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ESSENTIAL RESEARCH
Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.
B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.
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NEW TREATMENT ADDED BY A MEMBER
Avoid dairy
Dairy can cause sometimes be the cause of IBS.
40% of users reported improvements
1 review
Lifestyle
TRIED
TRYING
How effective is it?
REMOVE ANSWER
completely cured
significant improvement
minor improvement
no difference
worse than before
Helps with prevention
0 (0%)
0 (0%)
2 (40%)
3 (60%)
0 (0%)
NEW SYMPTOM ADDED BY A MEMBER
Yes
8
No
0
Bloating
100% reported this symptom
Any abnormal gas swelling, or increase in diameter of the abdominal area.
ESSENTIAL RESEARCH
The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects.
The study showed that fecal microbiota is significantly altered in IBS. Further studies on molecular mechanisms underlying these alterations are needed to elucidate the exact role of intestinal bacteria in IBS.
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CLINICAL TRIALRecruiting
Indiana University Gastrointestinal Motility Diagnosis Registry
Indianapolis, United States
All genders
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions. It will also help in promoting future research in gastroenterology motility disorders
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0REPLY1 YEAR AGO
NEW TREATMENT ADDED BY A MEMBER
Elimination diet
Eliminate foods that can cause IBS, then introduce them one at a time to determine which foods are causing symptoms.
Waiting for more user ratings
Lifestyle
TRIED
TRYING
How effective is it?
REMOVE ANSWER
completely cured
significant improvement
minor improvement
no difference
worse than before
Helps with prevention
Waiting for a few more ratings to show results.
PROGRESS UPDATE
TREATMENT
Avoid dairy made no difference
Peppermint oil made a minor improvement
Cannabis made a significant improvement
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SYMPTOM
Excessive gas marked as moderate
Bloating marked as moderate
Fatigue marked as severe
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1REPLY2 YEARS AGO
ESSENTIAL RESEARCH
Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome.
Factors contributing to the placebo effect can be progressively combined in a manner resembling a graded dose escalation of component parts. Non-specific effects can produce statistically and clinically significant outcomes and the patient-practitioner relationship is the most robust component.
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ESSENTIAL RESEARCH
Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses.
These results show that this form of early life stress results in an altered brain-gut axis and is therefore an important model for investigating potential mechanistic insights into stress-related disorders including depression and IBS.
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ESSENTIAL RESEARCH
Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome.
Global and deep molecular analysis of fecal samples indicates that patients with IBS have a different composition of microbiota. This information might be used to develop better diagnostics and ultimately treatments for IBS.
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CLINICAL TRIALCompleted
SAT vs Escitalopram for Rectal Hypersensitivity
2 Locations
All genders
Phase 2
Constipation is a common digestive disorder. After excluding dietary factors, drugs and other secondary causes, at least three broad pathophysiologic subtypes are recognized- dyssynergic defecation, constipation-predominant irritable bowel syndrome (IBS-C) and slow transit constipation (STC), all predominantly affect women and elderly. Many patients also demonstrate abnormal rectal perception with both rectal hyposensitivity and hypersensitivity being common. Recent surveys show that most constipated patients are dissatisfied with current therapy. Also, constipated patients showed significant psychological dysfunction and impaired quality of life. OBJECTIVE: To investigate a novel biofeedback technique of improving rectal hypersensitivity. METHODS: A large compliant balloon attached to a barostat was placed in the rectum in 8 patients with rectal hypersensitivity (urgency/pain threshold <30 mm Hg). Sensory deconditioning was performed by incremental balloon distensions (1-2 mmHg) until normal thresholds were reached.
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0REPLY1 YEAR AGO
ESSENTIAL RESEARCH
Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome.
These data show that UC and IBS are associated with similar molecular changes in serotonergic signaling mechanisms. While UC and IBS have distinct pathophysiologic properties, these data suggest that shared defects in 5-HT signaling may underlie the altered motility, secretion, and sensation. These findings represent the first demonstration of significant molecular alterations specific to the gut in patients with IBS and support the assertion that disordered gastrointestinal function in IBS involves changes intrinsic to the bowel.
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ABOUT
Irritable bowel syndrome (IBS) is a group of symptoms-including abdominal pain and changes in the pattern of bowel movements without any evidence of underlying damage. These symptoms occur over a long time, often years. It has been classified into four main types depending on whether diarrhea is common, constipation is common, both are common, or neither occurs very often (IBS-D, IBS-C, IBS-M, or IBS-U respectively). IBS negatively affects quality of life and may result in missed school or work. Disorders such as anxiety, major depression, and chronic fatigue syndrome are common among people with IBS.Wikipedia
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